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- Title
Rizatriptan benzoate-loaded dissolving microneedle patch for management of acute migraine therapy.
- Authors
Zhong, Chao; Zhang, Xiufeng; Sun, Yanfang; Shen, Zhong; Mao, Yanan; Liu, Tianqi; Wang, Rui; Nie, Lei; Shavandi, Amin; Yunusov, Khaydar E; Jiang, Guohua
- Abstract
In this study, dissolving microneedles (MNs) using polyvinyl alcohol (PVA) and poly (1-vinylpyrrolidone-co-vinyl acetate) (P(VP-co-VA)) as matrix materials were developed for transdermal delivery of rizatriptan benzoate (RB) for acute migraine treatment. In-vitro permeation studies were conducted to assess the feasibility of the as-fabricated dissolving MNs to release RB. Drug skin penetration were tested by Franz diffusion cells, showing an increase of the transdermal flux compared to passive diffusion due to the as-fabricated dissolving MNs having a sufficient mechanical strength to penetrate the skin and form microchannels. The pharmacological study in vivo showed that RB-loaded dissolving MNs significantly alleviated migraine-related response by up-regulating the level of 5-hydroxytryptamine (5-HT) and down-regulating the levels of calcitonin gene-related peptide (CGRP) and substance P (SP). In conclusion, the RB-loaded dissolving MNs have advantages of safety, convenience, and high efficacy over conventional administrations, laying a foundation for the transdermal drug delivery system treatment for acute migraine.
- Subjects
SUMATRIPTAN; CALCITONIN gene-related peptide; MIGRAINE; TRANSDERMAL medication; SUBSTANCE P; DRUG delivery systems
- Publication
Journal of Biomaterials Applications, 2024, Vol 38, Issue 9, p989
- ISSN
0885-3282
- Publication type
Article
- DOI
10.1177/08853282241237323