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- Title
Development of a salmon protein hydrolysate that lowers blood pressure.
- Authors
Ewart, H. Stephen; Dennis, Dorothy; Potvin, Michael; Tiller, Christa; Lian-hua Fang; Ran Zhang; Xiao-ming Zhu; Curtis, Jonathan; Cloutier, Sylvie; Guanhua Du; Barrow, Colin J.
- Abstract
A salmon protein hydrolysate (SPH) was developed containing several angiotensin I-converting enzyme (ACE) inhibitory tripeptides the most abundant of which were Val-Leu-Trp, Val-Phe-Tyr, and Leu-Ala-Phe. Simulated digestion experiments showed that active constituents of SPH would survive in the digestive tract and be available for absorption into the bloodstream. In fact, ACE inhibitory activity was improved following simulated digestion suggesting that there were larger peptides in SPH that might contribute to bioactivity in vivo. A single oral dose (1,500 mg/kg body mass) of SPH significantly lowered blood pressure in spontaneously hypertensive rats (SHR). The treatment of SHR with either SPH fraction (<3,000 Da) or SPH fraction (>3,000 Da) reduced blood pressure. We conclude that the ability of SPH to lower blood pressure is due to a combination of ACE inhibitory tripeptides as identified, as well as additional unknown, peptide species that are generated during digestion of SPH in the gastrointestinal tract.
- Subjects
ANGIOTENSIN I; FUNCTIONAL foods; REGULATION of blood pressure; RENIN-angiotensin system; LABORATORY rats
- Publication
European Food Research & Technology, 2009, Vol 229, Issue 4, p561
- ISSN
1438-2377
- Publication type
Article
- DOI
10.1007/s00217-009-1083-3