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- Title
Morphological Effects of Combined Systemic Administration of Fluoxetine and Sildenafil in the Murine Hippocampus.
- Authors
Mahmoodi, M.; Shahidi, S.; Hashemi-Firouzi, N.; Komaki, A.
- Abstract
We examined the effects of fluoxetine, a selective serotonin re-uptake inhibitor, of sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, and of combined administration of these agents on morphometric characteristics of principal cells of the murine hippocampus. Fluoxetine (5 mg/kg), sildenafil (2 mg/kg), or a combination of these drugs in the above doses were administered i.p. daily for 2 weeks to male mice. Hippocampal sections (5 mm thick) were stained with hematoxylin/eosin. Both drugs and their combination evoked no considerable changes in the dimensions of pyramidal cells in the CA1 and CA2 areas and in the dentate gyrus (DG), except for a trend toward some decrease of this parameter after fluoxetine injections in the CA1 area. Combined administration of fluoxetine and sildenafil provided significant decreases in the density of pyramidal neurons (their mean number per 10 mm of the slice) in the CA1 area and DG. Isolated administration of fluoxetine resulted in significant but less intense decreases in the density of principal cells in the CA2 area and DG. Possible mechanisms of the effects of the mentioned drugs are discussed. Further studies of interaction between fluoxetine and sildenafil in their effects on morphological and physiological properties of cells in different subregions of the hippocampus are recommended.
- Subjects
HIPPOCAMPUS (Brain); FLUOXETINE; SILDENAFIL; COMBINATION drug therapy; DRUG administration; CELL morphology
- Publication
Neurophysiology, 2013, Vol 45, Issue 4, p293
- ISSN
0090-2977
- Publication type
Article
- DOI
10.1007/s11062-013-9371-8