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- Title
Rapid Changes in Serum Testosterone in Men With Newly Diagnosed Type 2 Diabetes With Intensive Insulin and Metformin.
- Authors
Hu, Yun; Ding, Bo; Shen, Yun; Yan, Reng-Na; Li, Feng-Fei; Sun, Rui; Jing, Ting; Lee, Kok-Onn; Ma, Jian-Hua
- Abstract
<bold>Objective: </bold>To investigate the effect of metformin on testosterone levels in men with type 2 diabetes mellitus (T2DM).<bold>Research Design and Methods: </bold>Seventy men with newly diagnosed drug-naive T2DM and HbA1c >9.0% (75 mmol/mol) were treated with intensive insulin pump therapy for 5 days to achieve glucose normalization. They were randomized to control (continued on intensive insulin only) and metformin (plus metformin) groups (1:1) for 1 month. Testosterone was measured at baseline, randomization, and after 1-month treatment.<bold>Results: </bold>Total, free, and bioavailable testosterone increased significantly within 5 days (all P < 0.001). After 1 month, compared with the control group, the metformin group had lower total (12.7 vs. 15.3 nmol/L), free (0.20 vs. 0.24 nmol/L), and bioavailable (4.56 vs. 5.31 nmol/L) testosterone (all P < 0.05).<bold>Conclusions: </bold>In men with T2DM, 1-month oral metformin may decrease serum testosterone levels independent of blood glucose control. The effects of long-term metformin on testosterone in men need further study.
- Subjects
TYPE 2 diabetes; METFORMIN; INSULIN; TESTOSTERONE; BLOOD sugar
- Publication
Diabetes Care, 2021, Vol 44, Issue 4, p1059
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc20-1558