We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
One‐Step and Mild Synthesis of 3‐(1,3,4‐Oxadiazol‐2‐Yl)isoindolin‐1‐Ones Through Ugi Four‐Component Domino Dicyclization.
- Authors
Sun, Mei; Zeng, Chong‐Yang; Zhang, En‐Shen; Zhang, Qiang; Chen, Kai; Xu, Yu‐Gu; Fan, Mei‐Xia; He, Meng‐Ru; Shi, Jing‐Hui; Ding, Ming‐Wu
- Abstract
A novel and efficient Ugi four‐component domino dicyclization strategy has been developed for one‐step constructing diverse 3‐(1,3,4‐oxadiazol‐2‐yl)isoindolin‐1‐ones with good yields, without the need for additional additives. This domino dicyclization process underwent three consecutive reactions including Ugi, aza‐Wittig and N‐acylation by utilizing (N‐isocyanimine)triphenylphosphorane, methyl 2‐formylbenzoate, primary amines, and carboxylic acids. The initial biological activity testing revealed that compound 5 i exhibited good antifungal activity against certain fungi and demonstrated versatile applications in the fields of pesticide chemistry.
- Subjects
ANTIFUNGAL agents; CARBOXYLIC acids; PESTICIDES; AMINES
- Publication
Asian Journal of Organic Chemistry, 2024, Vol 13, Issue 6, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202400036