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- Title
Effect of Dapagliflozin in DAPA-HF According to Background Glucose-Lowering Therapy.
- Authors
Docherty, Kieran F.; Jhund, Pardeep S.; Bengtsson, Olof; DeMets, David L.; Inzucchi, Silvio E.; Køber, Lars; Kosiborod, Mikhail N.; Langkilde, Anna Maria; Martinez, Felipe A.; Sabatine, Marc S.; Sjöstrand, Mikaela; Solomon, Scott D.; McMurray, John J.V.; Diez, Mirta; Sassone, Sonia; Aizenberg, Diego; Talavera, Maria; Mercau, Guillermo; Martinez, Diego; Albisu, Juan
- Abstract
<bold>Objective: </bold>To determine whether the benefits of dapagliflozin in patients with heart failure and reduced ejection fraction (HFrEF) and type 2 diabetes in the Dapagliflozin And Prevention of Adverse-Outcomes in Heart Failure trial (DAPA-HF) varied by background glucose-lowering therapy (GLT).<bold>Research Design and Methods: </bold>We examined the effect of study treatment by the use or not of GLT and by GLT classes and combinations. The primary outcome was a composite of worsening heart failure (hospitalization or urgent visit requiring intravenous therapy) or cardiovascular death.<bold>Results: </bold>In the 2,139 type 2 diabetes patients, the effect of dapagliflozin on the primary outcome was consistent by GLT use or no use (hazard ratio 0.72 [95% CI 0.58-0.88] vs. 0.86 [0.60-1.23]; interaction P = 0.39) and across GLT classes.<bold>Conclusions: </bold>In DAPA-HF, dapagliflozin improved outcomes irrespective of use or no use of GLT or by GLT type used in patients with type 2 diabetes and HFrEF.
- Subjects
DAPAGLIFLOZIN; TYPE 2 diabetes; HEART failure patients; INTRAVENOUS therapy; PEOPLE with diabetes; BENZENE; RESEARCH; COMBINATION drug therapy; RESEARCH methodology; BLOOD sugar; GLYCOSIDES; MEDICAL cooperation; EVALUATION research; TREATMENT effectiveness; COMPARATIVE studies; RANDOMIZED controlled trials; HOSPITAL care; BLIND experiment; KAPLAN-Meier estimator; METFORMIN; STROKE volume (Cardiac output); HEART failure; PROPORTIONAL hazards models; LONGITUDINAL method; DISEASE complications
- Publication
Diabetes Care, 2020, Vol 43, Issue 11, p2878
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc20-1402