We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Effect of Brewed Robusta Coffee Leaves on Insulin Levels and HOMA-IR Index in Metabolic Syndrome Rats.
- Authors
Widyastuti, Nurmasari; Anjani, Gemala; Almira, Vita Gustin; Putri, Suci Eka; Pratiwi, Amali Rica; Prawira-Atmaja, M. Iqbal
- Abstract
Introduction: Central obesity and insulin resistance have been known as the main risk factors for metabolic syndrome. Robusta coffee leaves could be a functional food to prevent metabolic syndrome with phytochemical compounds. This study aimed to prove the effectiveness of the administration of brewed Robusta coffee leaves on insulin levels and HOMA-IR index in metabolic syndrome rats. Material and Methods: Male Wistar rats (6 weeks old, 150-200 g, n = 36) were divided into six groups (n = 6 rats/group): normal control group (K1), metabolic syndrome control group without treatment (K2), mangiferin treatment group (X1), brewed Robusta coffee leaves 0.09 g/200BW group (X2), brewed Robusta coffee leaves 0.18 g/200BW group (X3), brewed Robusta coffee leaves 0.36 g/200BW group (X4). Besides the K1 group, the other groups were given a high-fat-fructose diet. Each dose of coffee leaves was brewed with 3.6 mL of water at 70°C for 10 minutes. The intervention was given for 28 days. Results: There was a significant increase in insulin levels (p<0.000) in all groups and a significant decrease in the HOMA-IR index in treatment groups (p<0.000). Conclusions: The administration of brewed Robusta coffee leaves increased insulin levels, and decreased the HOMA-IR index in metabolic syndrome rats with the most effective dose being 0.36 g/200gBW.
- Subjects
K2 (Pakistan : Mountain); RATS; COFFEE brewing; METABOLIC syndrome; INSULIN resistance; LABORATORY rats; INSULIN; FRUCTOSE
- Publication
Romanian Journal of Diabetes Nutrition & Metabolic Diseases, 2020, Vol 27, Issue 1, p16
- ISSN
2068-8245
- Publication type
Article
- DOI
10.46389/rjd-2020-1004