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- Title
Porcine ear skin: an in vitro model for human skin.
- Authors
Jacobi, Ute; Kaiser, Marco; Toll, Rani; Mangelsdorf, Susanne; Audring, Heike; Otberg, Nina; Sterry, Wolfram; Lademann, Juergen
- Abstract
Background/purpose: Porcine ear skin is used in studies of percutaneous penetration as a substitute for human skin. The structure of this tissue, including hair follicles, was studied qualitatively and quantitatively in comparison with human skin. Methods: Sections of shock-frozen biopsies, biopsies embedded in paraffin and cyanoacrylate skin surface biopsies were investigated using microscopy. The thickness of the different skin layers and the follicular characteristics were determined. Results: The thickness of the stratum corneum was 17–28 μm, whereas the viable epidermis was 60–85 μm thick. On 1 cm2, 11–25 hairs were detected, showing a diameter of 58–97 μm and a maximal extension depth of 0.96–1.38 mm into the skin. The orifices of the porcine infundibula showed a diameter of approximately 200 μm. Conclusions: The results obtained are similar to those of human skin, indicating the suitability of this porcine tissue as a model for human skin.
- Subjects
HISTOLOGY; SKIN; HUMAN anatomy; CYANOACRYLATES; BIOPSY; TISSUES
- Publication
Skin Research & Technology, 2007, Vol 13, Issue 1, p19
- ISSN
0909-752X
- Publication type
Article
- DOI
10.1111/j.1600-0846.2006.00179.x