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- Title
A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis.
- Authors
Kou, Ikuyo; Watanabe, Kota; Takahashi, Yohei; Momozawa, Yukihide; Khanshour, Anas; Grauers, Anna; Zhou, Hang; Liu, Gang; Fan, Yan-Hui; Takeda, Kazuki; Ogura, Yoji; Zhou, Taifeng; Iwasaki, Yusuke; Kubo, Michiaki; Wu, Zhihong; Matsumoto, Morio; Japan Scoliosis Clinical Research Group (JSCRG); Texas Scottish Rite Hospital for Children Clinical Group (TSRHCCG); Einarsdottir, Elisabet; Kere, Juha
- Abstract
Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity and has a significant genetic background. Genome-wide association studies (GWASs) identified several susceptibility loci associated with AIS. Among them is a locus on chromosome 6q24.1 that we identified by a GWAS in a Japanese cohort. The locus is represented by rs6570507 located within GPR126. To ensure the association of rs6570507 with AIS, we conducted a meta-analysis using eight cohorts from East Asia, Northern Europe and USA. The analysis included a total of 6,873 cases and 38,916 controls and yielded significant association (combined P = 2.95 × 10−20; odds ratio = 1.22), providing convincing evidence of the worldwide association between rs6570507 and AIS susceptibility. In silico analyses strongly suggested that GPR126 is a susceptibility gene at this locus.
- Publication
Scientific Reports, 2018, Vol 8, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-018-29011-7