We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Risk factors for incident diabetes mellitus among HIV-infected patients receiving combination antiretroviral therapy in Taiwan: a case–control study.
- Authors
Lo, Y.-C.; Chen, M.-Y.; Sheng, W.-H.; Hsieh, S.-M.; Sun, H.-Y.; Liu, W.-C.; Wu, P.-Y.; Wu, C.-H.; Hung, C.-C.; Chang, S.-C.
- Abstract
Objectives Recent studies suggest that patients with HIV infection are at increased risk for incident diabetes mellitus (DM). We investigated the incidence and risk factors of DM among HIV-infected patients receiving combination antiretroviral therapy (CART) in Taiwan. Methods Incident cases of DM were identified among HIV-infected patients at the National Taiwan University Hospital between 1993 and 2006. A retrospective case–control study was conducted after matching cases with controls for sex, age at HIV diagnosis, year of HIV diagnosis, mode of HIV transmission and baseline CD4 lymphocyte count. A multivariate analysis was performed to identify risk factors for incident DM among HIV-infected patients. Results In 824 HIV-infected patients eligible for analysis, 50 cases of incident DM were diagnosed, resulting in an incidence of 13.1 cases per 1000 person-years of follow-up. In total, 100 matched controls were identified. Risk factors for incident DM were a family history of DM [odds ratio (OR) 2.656; 95% confidence interval (CI) 1.209–5.834], exposure to zidovudine (OR 3.168; 95% CI 1.159–8.661) and current use of protease inhibitors (OR 2.528; 95% CI 1.186–5.389). Conclusions Incident DM was associated with a family history of DM, exposure to zidovudine and current use of protease inhibitors in HIV-infected patients receiving CART in Taiwan.
- Subjects
TAIWAN; HIV-positive persons; DIABETES risk factors; HIGHLY active antiretroviral therapy; ANTIRETROVIRAL agents; AZIDOTHYMIDINE; RETROSPECTIVE studies; PROTEASE inhibitors
- Publication
HIV Medicine, 2009, Vol 10, Issue 5, p302
- ISSN
1464-2662
- Publication type
Article
- DOI
10.1111/j.1468-1293.2008.00687.x