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- Title
Pellagra secondary to 5-fluorouracil.
- Authors
Stevens, H. P.; Ostlere, L. S.; Begent, R. H. J.; Dooley, J. S.; Rustin, M. H. A.
- Abstract
The development of pellagra in a patient treated with 5-fluorouracil for malignant disease is reported. The aetiology of pellagra in this patient is discussed. and the reasons for possible under-diagnosis of pellagra in association with malignant disease considered. We report a patient who presented with the typical skin changes of pellagra. The rash, and an associated acute deterioration in cerebral function, were exacerbated by treatment with 5-fluorouracil. The importance of considering nicotinic-acid deficiency in patients with malignant disease has not been emphasized in the literature.
- Subjects
SKIN diseases; ANTINEOPLASTIC agents; FLUOROURACIL; ETIOLOGY of diseases; NIACIN; MEDICAL literature
- Publication
British Journal of Dermatology, 1993, Vol 128, Issue 5, p578
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1993.tb00240.x