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- Title
Radiobiological studies in the naevoid basal cell carcinoma syndrome.
- Authors
Newton, Julia A.; Black, Anne Kobza; Arlett, C. F.; Cole, Jane
- Abstract
The naevoid basal cell carcinoma syndrome is described in a 43-year-old male. The response of dividing fibroblasts from this patient to the lethal effects of ionizing radiation was indistinguishable from that of a normal control: mean inactivation dose (D) = 1.74 Gy and 1.68 Gy, respectively. However, these cells were defective in the repair of potentially lethal damage (D= 2.36 Gy and 3.26 Gy, respectively). The response to radiation of G0 T lymphocytes derived from the patient was similar to that of the control. The frequency of mutant circulating T lymphocytes resistant to 6-thioguanine was 17 × 106 which was elevated when compared with age-matched controls. These results suggest an abnormality in the response of the fibroblasts to ionizing radiation damage.
- Subjects
BASAL cell carcinoma; SKIN cancer; FIBROBLASTS; IONIZING radiation; LYMPHOCYTES; RADIATION injuries
- Publication
British Journal of Dermatology, 1990, Vol 123, Issue 5, p573
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1990.tb01473.x