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- Title
Gamma-interferon induced human keratinocyte HLA-DR synthesis: the role of dermal activated T lymphocytes.
- Authors
Barker, J.N.W.N.; Navsaria, H.A.; Leigh, I.M.; MacDonald, D.M.
- Abstract
Experiments were performed to examine the hypothesis that the surface expression of HLADR by keratinocytes in certain disease states is conferred by the activity of gamma-interferon, derived from dermal activated T lymphocytes. In vivo studies revealed a spatial relationship between keratinocyte HLA-DR expression and activated T lymphocytes within the dermal inflammatory infiltrate. In vitro studies confirmed that gamma-interferon can induce keratinocyte synthesis of HLA-DR. These results suggest that, in vivo, gamma-interferon produced by activated T lymphocytes induces keratinocyte HLA-DR synthesis and expression.
- Subjects
KERATINOCYTES; T cells; INTERFERONS; LYMPHOKINES; SKIN diseases
- Publication
British Journal of Dermatology, 1988, Vol 119, Issue 5, p567
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1988.tb03466.x