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- Title
Oxytocin and hypothalamo-pituitaryadrenal axis.
- Authors
Yeğen, Berrak Ç.
- Abstract
Upon exposure to different types of stressors, neuroendocrine and behavioral responses that include the activation of the hypothalamus-pituitary-adrenal (HPA) axis are given to allow the individuals to cope with stress conditions. It was proven that oxytocin, a nonapeptide released from the posterior pituitary, has behavioral and stress-attenuating effects by dampening HPA activity. On the other hand, the neuropeptide was also shown to exert anti-inflammatory effects through the modulation of immune and inflammatory processes in several experimental models of tissue injury. The findings of recent studies suggest that the anti-inflammatory effect of oxytocin depends on its role on HPA axis activity and subsequent release of cortisol. Thus, oxytocin seems to restrain the activity within the HPA-axis, which becomes overactive during many inflammatory processes.
- Subjects
OXYTOCIN; HYPOTHALAMIC-pituitary-adrenal axis; NEUROENDOCRINE cells; NEUROHYPOPHYSIS; NEUROPEPTIDES
- Publication
Marmara Pharmaceutical Journal, 2010, Vol 14, Issue 2, p61
- ISSN
1309-0801
- Publication type
Article