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- Title
Synthesis, Spectroscopy, Semi-empirical and Biological Activities of Organotin(IV) Complexes with o-Isopropyl Carbonodithioic Acid.
- Authors
Javed, Fatima; Ali, Saqib; Shahzadi, Saira; Khalid, Nasir; Tabassum, Saira; Khan, Imran; Sharma, Saroj K.; Qanungo, Kushal
- Abstract
New organotin(IV) complexes have been synthesized by treating potassium o-isopropyl carbonodithioate with R2SnCl2/R3SnCl in 1 : 2/1 : 1 M/L ratio. All complexes have been characterized by IR and NMR (1H, 13C) spectroscopy. IR results shows that ligand acts as bidentate which is also confirmed by semi-empirical study. NMR data reveals four coordinated geometry in solution. Computed positive heat of formation shows that complex 5 is thermodynamically unstable. UV/visible spectroscopy was used to assess the mode of interaction and binding of the complexes with DNA which shows that complex 5 exhibits higher binding constant as compared to complex 3. In protein kinase inhibition assay, compound 3 was found most active, while other biological activities shows that triorganotin(IV) complexes are biologically more active as compared to diorganotin(IV) complexes.
- Subjects
PROTEIN kinases; PHOSPHOTRANSFERASES; THERMOCHEMISTRY; CHEMICAL reactions; DEGREE of ionization; CHEMIEXCITATION; CHEMICAL processes; CHEMICAL energy
- Publication
Journal of the Chinese Chemical Society, 2015, Vol 62, Issue 8, p728
- ISSN
0009-4536
- Publication type
Article
- DOI
10.1002/jccs.201500235