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- Title
Inflammation and structural changes of splenic lymphoid tissue in visceral leishmaniasis: A study on naturally infected dogs.
- Authors
SANTANA, C. C.; VASSALLO, J.; DE FREITAS, L. A. R.; OLIVEIRA, G. G. S.; PONTES-DE-CARVALHO, L. C.; DOS-SANTOS, W. L. C.
- Abstract
The aim of this study was to identify splenic immuno-inflammatory patterns associated with natural infection by Leishmania chagasi . Spleen samples were obtained from 72 stray dogs from an endemic area of visceral leishmaniasis. The animals were grouped into four categories as follows: (i) potentially resistant to visceral leishmaniasis, with a positive leishmanin skin test result, and negative splenic culture for Leishmania parasites (ii) potentially susceptible to visceral leishmaniasis, with a negative leishmanin skin test and positive splenic culture for Leishmania (iii) infected with undefined susceptibility status, with a positive leishmanin skin test and positive splenic culture for Leishmania , and (iv) noninfected, with a negative leishmanin skin test, negative splenic culture for Leishmania , and negative serology for anti-Leishmania antibodies. Histopathological analyses showed that there was a higher frequency of perisplenitis (18/25, P < 0·0001), granuloma (7/25, P = 0·0102), structural disorganization (14/25, P < 0·0001), and atrophy of the lymphoid follicles (20/25, P = 0·0036) and of the marginal zone (15/25, P = 0·0025) in the potentially susceptible group than in the other groups. The data presented here show changes in the white pulp of the spleen that are associated with naturally acquired visceral leishmaniasis.
- Subjects
LEISHMANIA; SPLEEN diseases; SKIN tests; SEROLOGY; LYMPHOID tissue
- Publication
Parasite Immunology, 2008, Vol 30, Issue 10, p515
- ISSN
0141-9838
- Publication type
Article
- DOI
10.1111/j.1365-3024.2008.01051.x