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- Title
Human aryl hydrocarbon receptor nuclear translocator gene (ARNT) D/N511 polymorphism.
- Authors
Cao, Henian; Hegele, Robert A.
- Abstract
Abstract We found a novel A to C change in codon 511 of the ARNT gene, which predicted the substitution of Asn (AAC) for Asp (GAC) at this position. Amplification using mismatched primers allowed the ARNT D/N511 polymorphism to be detected by digestion with endonuclease TthlllI. The frequency of the ARNT N511 allele was 0.019 in Caucasians and 0.026 in Africans. Because of the importance of the ARNT gene product in the metabolism of xenobiotics, this polymorphism may be useful in the study of associations with metabolic phenotypes and in pharmacogenetic studies.
- Subjects
GENES; GENETIC polymorphisms; ENDONUCLEASES; XENOBIOTICS
- Publication
Journal of Human Genetics, 2000, Vol 45, Issue 2, p92
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1007/s100380050018