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- Title
Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan<sup>1</sup>.
- Authors
Chi-Jung Wu; Wei-Lun Liu; Chih-Cheng Lai; Chien-Ming Chao; Wen-Chien Ko; Hsuan-Chen Wang; Ching-Tzu Dai; Ming-I Hsieh; Pui-Ching Choi; Jia-Ling Yang; Yee-Chun Chen; Wu, Chi-Jung; Liu, Wei-Lun; Lai, Chih-Cheng; Chao, Chien-Ming; Ko, Wen-Chien; Wang, Hsuan-Chen; Dai, Ching-Tzu; Hsieh, Ming-I; Choi, Pui-Ching
- Abstract
In a multicenter study, we determined a prevalence rate of 4% for azole-resistant Aspergillus fumigatus in Taiwan. Resistance emerged mainly from the environment (TR34/L98H, TR34/L98H/S297T/F495I, and TR46/Y121F/T289A mutations) but occasionally during azole treatment. A high mortality rate observed for azole-resistant aspergillosis necessitates diagnostic stewardship in healthcare and antifungal stewardship in the environment.
- Subjects
TAIWAN; ASPERGILLUS fumigatus; DRUG resistance in microorganisms; ASPERGILLOSIS; ANTIFUNGAL agents; PROTEINS; RESEARCH; HETEROCYCLIC compounds; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; ASPERGILLUS; MICROBIAL sensitivity tests; PHARMACODYNAMICS
- Publication
Emerging Infectious Diseases, 2020, Vol 26, Issue 4, p806
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2604.190840