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- Title
Oseltamivir-resistant influenza virus A (H1N1), Europe, 2007-08 season.
- Authors
Meijer A; Lackenby A; Hungnes O; Lina B; van-der-Werf S; Schweiger B; Opp M; Paget J; van-de-Kassteele J; Hay A; Zambon M; European Influenza Surveillance Scheme; Meijer, Adam; Lackenby, Angie; Hungnes, Olav; Lina, Bruno; van-der-Werf, Sylvie; Schweiger, Brunhilde; Opp, Matthias; Paget, John
- Abstract
In Europe, the 2007-08 winter season was dominated by influenza virus A (H1N1) circulation through week 7, followed by influenza B virus from week 8 onward. Oseltamivir-resistant influenza viruses A (H1N1) (ORVs) with H275Y mutation in the neuraminidase emerged independently of drug use. By country, the proportion of ORVs ranged from 0% to 68%, with the highest proportion in Norway. The average weighted prevalence of ORVs across Europe increased gradually over time, from near 0 in week 40 of 2007 to 56% in week 19 of 2008 (mean 20%). Neuraminidase genes of ORVs possessing the H275Y substitution formed a homogeneous subgroup closely related to, but distinguishable from, those of oseltamivir-sensitive influenza viruses A (H1N1). Minor variants of ORVs emerged independently, indicating multiclonal ORVs. Overall, the clinical effect of ORVs in Europe, measured by influenza-like illness or acute respiratory infection, was unremarkable and consistent with normal seasonal activity.
- Publication
Emerging Infectious Diseases, 2009, Vol 15, Issue 4, p552
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid1504.181280