We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
High Rate of Mobilization for bla<sub>CTX-M</sub>s.
- Authors
Barlow, Miriam; Reik, Rebecca A.; Jacobs, Stephen D.; Medina, Mónica; Meyer, Matthew P.; McGowan Jr., John E.; Tenover, Fred C.
- Abstract
We constructed a phylogenetic analysis of class A β-lactamases and found that the blaCTX-Ms have been mobilized to plasmids ≈10 times more frequently than other class A β-lactamases. We also found that the blaCTX-Ms are descended from a common ancestor that was incorporated in ancient times into the chromosome of the ancestor of Kluyvera species through horizontal transfer. Considerable sequence divergence has occurred among the descendents of that ancestral gene sequence since that gene was inserted. That divergence has mainly occurred in the presence of purifying selection, which indicates a slow rate of evolution for blaCTX-Ms in the pre-antimicrobial drug era.
- Subjects
BETA lactamases; MASS mobilization; CHROMOSOMES; PLASMID genetics; GENES; ANTI-infective agents
- Publication
Emerging Infectious Diseases, 2008, Vol 14, Issue 3, p423
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid1403.070405