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- Title
Matrine Suppresses Production of IL-23/IL-17 and Ameliorates Experimental Autoimmune Encephalomyelitis.
- Authors
Zhao, Xiaoyu; Kan, Quancheng; Zhu, Lin; Zhang, Guang-Xian
- Abstract
Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flave, has been suggested to possess immunomodulatory characteristics; however, whether it is effective in multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS), is not known. Our aim was to bridge this gap by investigating the possible therapeutic effects of MAT on experimental autoimmune encephalomyelitis (EAE), an animal model of MS. We have found that, compared to the untreated controls, MAT-treated rats showed a significant decrease in clinical scores, in CNS infiltration of inflammatory cells (including CD4+, CD8+ T cells and macrophages) and demyelination. Furthermore, serum levels of IL-23 and IL-17 showed a marked reduction after MAT treatment, particularly in rats treated with higher doses of MAT. This study demonstrates that administration of MAT, as a natural compound, might be a novel therapy for autoimmune disorders such as MS.
- Subjects
THERAPEUTIC use of alkaloids; MEDICAL botany; ANIMAL experimentation; AUTOIMMUNE diseases; CENTRAL nervous system; ENCEPHALITIS; ENZYME-linked immunosorbent assay; EXPERIMENTAL design; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGICAL adjuvants; INTERLEUKINS; MULTIPLE sclerosis; NEUROLOGICAL disorders; RATS; SPINAL cord; T-test (Statistics); U-statistics; PHARMACODYNAMICS; SYMPTOMS
- Publication
American Journal of Chinese Medicine, 2011, Vol 39, Issue 5, p933
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/S0192415X11009317