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- Title
Effects of Radix scutellariae and Rhizoma atractylodis on LPS-induced abortion and the uterine IL-10 contents in mice.
- Authors
Zhong X; Shi W; Ma A; Gong X; Zhai X; Zhang T; Wang X
- Abstract
In the present study, lipopolysaccharide (LPS) was injected i.v. via the tail vein (0.1 mug per mouse) to induce abortion (embryo resorption) in Kunming mice. The interleukin 10 (IL-10) contents in the uterus were assayed by ELISA. The results revealed that the IL-10 level was significantly decreased in the LPS-induced abortion group of mice compared to the controls. Use of Pentoxifylline (PXF), or a combination of Radix scutellariae and Rhizoma atractylodis reversed the LPS effects: bringing down the fetal resorption rate, and increasing the IL-10 level significantly. The study indicates that the anti-abortive effects of PXF and the combination of Radix scutellariae and Rhizoma atractylodis are closely related to up-regulation of the Th2 cytokine IL-10 at the maternal fetal interface.
- Publication
American Journal of Chinese Medicine, 2008, Vol 36, Issue 1, p141
- ISSN
0192-415X
- Publication type
Journal Article
- DOI
10.1142/s0192415x08005655