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- Title
Cell surface receptor function of amyloid precursor protein that activates Ser/Thr kinases.
- Authors
Murayama, Y; Takeda, S; Yonezawa, K; Giambarella, U; Nishimoto, I; Ogata, E
- Abstract
Amyloid precursor protein (APP) has been shown to serve as a G(o)-coupled receptor in cell-free systems [Okamoto et al: J Biol Chem 1995;270:4205-4208]. However, it has not been known whether APP exerts intracellular signaling functions in living cells. In this study, we show that stimulation of APP by anti-APP antibody as well as by a mutation found in familial Alzheimer's disease results in activation of a specific set of mitogen-activated protein kinases in multiple vertebrate cells. We conclude that APP acts as a cell surface receptor of biological relevance that turns on specific Ser/Thr kinases, and suggest that the signaling function of APP is a potential target of familial Alzheimer's disease mutations.
- Publication
Gerontology, 1996, Vol 42, Issue 1, p2
- ISSN
0304-324X
- Publication type
journal article