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- Title
Synthesis and analgesic and antimicrobial activities of 2-(3,3-dialkyl-1,2,3,4-tetrahydroisoquinolin-1-idene)ethanoic acid ureides.
- Authors
Surikova, O.; Limanskii, E.; Aleksandrova, G.; Kir'yanova, I.; Makhmudov, R.; Mikhailovskii, A.
- Abstract
A series of 2-(3,3-dialkyl-1,2,3,4-tetrahydroisoquinolin-1-idene)ethanoic acid ureides were synthesized via cyclocondensation of dialkylbenzylcarbinols and cyanoacetylurea. Experiments showed that hydrochlorides of the synthesized compounds exhibited an analgesic effect that surpassed that of metamizole sodium. It was established that four (of a total of seven) synthesized compounds possessed minimum inhibiting concentrations of about 31.2 μg/mL against Staphylococcus aureus.
- Subjects
ANALGESICS; ANTI-infective agents; ACETIC acid; UREIDES; QUINOLINE; STAPHYLOCOCCUS aureus; METHANOL; CHEMICAL synthesis; THERAPEUTICS
- Publication
Pharmaceutical Chemistry Journal, 2013, Vol 47, Issue 4, p198
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-013-0926-1