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- Title
Intravoxel incoherent motion diffusion-weighted imaging and shear wave elastography for evaluating peritumoral liver ?brosis after transarterial chemoembolization in a VX2 rabbit liver tumor model.
- Authors
Zhimei Cheng; Qin Yang; Huizhou He; Ran Li; Xueying Li; Hongyu Jiang; Xuya Zhao; Junxiang Li; Lizhou Wang; Shi Zhou; Shuai Zhang
- Abstract
In this study,we sought to evaluate changes in peritumoral fibrosis after transarterial chemoembolization (TACE) in a rabbit VX2 liver tumor model using intravoxel incoherent motion diffusion-weighted imaging (IVIM DWI) and ultrasound shear wave elastography (SWE). A total of 20 rabbits underwent implantation of VX2 tumor tissues in the left lobe of the liver. The rabbits were randomly divided into an experimental group (n = 10) or a control group (n =10).Those in the experimental group were treated with an emulsion of lipiodol and pirarubicin through a microcatheter 2--3 weeks after implantation; those in the control group were treatedwith sterilewater. Comparedwith the control group, the true diffusion coefficient (D) and pseudodiffusion coefficient (D*) values in liver tissues were significantly lower (p < 0.05 for all) and liver stiffness values (LSV) (10.58 ± 0.89 kPa) were higher in the experimental group (7.65 ± 0.86 kPa; p < 0.001). The median stage of liver fibrosis based onMETAVIR scoreswas 1 (1,1) in the control group and 2 (2,3) in the experimental group (Z =4.15,p < 0.001). D, D*, and LSV were significantly correlated with pathologic staining in the assessment of liver fibrosis (r = -0.54 p = 0.015; r = -0.50, p = 0.025; r =0.91,p < 0.001; respectively). These data suggest that TACE aggravates liver injury and liver fibrosis, especially surrounding the tumor, in a rabbit VX2 liver tumor model. IVIM DWI and SWE can be used to evaluate the change in liver fibrosis.
- Subjects
CHEMOEMBOLIZATION; DIFFUSION magnetic resonance imaging; SHEAR waves; LIVER tumors; HEPATIC fibrosis; FIBROSIS
- Publication
Frontiers in Physiology, 2022, Vol 13, p01
- ISSN
1664-042X
- Publication type
Article
- DOI
10.3389/fphys.2022.893925