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- Title
Matrix Metalloproteinase-13 Can Be Used As an Independent Diagnostic and Prognostic Marker for Breast Carcinoma.
- Authors
Shrivastava, Swati; Singh, Neelima; Nigam, Akshay Kumar
- Abstract
Background & Objectives: Matrix Metalloproteinase-13(MMP-13) or Collagenase3 overexpresses in breast carcinoma and promotes tumor progression. Therefore, this study aims to investigate the clinical significance of serum matrix metalloproteinase-13 levels in various stages of breast carcinoma. Methods: The study was conducted in the Department of Biochemistry, G. R. Medical College, Gwalior using the Case-control study design. Total 235 human subjects were taken in the study. Out of which 100 normal age matched healthy subjects were considered as controls and 135 breast cancer patients. Serum levels of MMP-13 were estimated by ELISA technique while CA 15.3 and CA 125 levels by ELFA technique. Biochemical parameters - Alkaline Phosphatase, Acid Phosphatase and Calcium levels were determined by using fully automated analyzer using commercially available kits according to manufacturer instructions. Hematological parameters were determined by using Sysmex automated analyzer. Independent sample t- test and one-way ANOVA in combination with Tukey HSD along with ROC curve analysis was done for evaluating results. Results & Conclusion: Serum levels of MMP-13 were significantly higher (p<0.001) in breast cancer subjects as compared to controls. MMP-13 was found highly sensitive (100%) and specific (92.50%) with p<0.001 when compared with other tumor markers and biochemical parameters. So, MMP-13 can be used as an independent diagnostic and prognostic marker for breast carcinoma.
- Subjects
MATRIX metalloproteinases; CARCINOMA
- Publication
National Journal of Integrated Research in Medicine, 2017, Vol 8, Issue 2, p15
- ISSN
2230-9969
- Publication type
Article