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- Title
VARIABLE CONTRIBUTION OF NITRIC OXIDE TO ENDOTHELIUM-DEPENDENT RELAXATION OF ISOLATED RAT ARTERIES: PHYSIOLOGICAL AND MORPHOLOGICAL INFLUENCES.
- Authors
Oprisa, Cristina; Tucaliuc, Elena Simona; Serban, Ionela Lacramioara; Paduraru, D.; Serban, D. N.; Mungiu, O. C.
- Abstract
The relative contribution of nitric oxide to arterial endothelium-dependent relaxation is influenced by various factors, including basic ones, such as vessel caliber and location, the level and mechanisms of precontraction, the agent inducing endothelium-dependent relaxation. Our long-term objective is to study certain aspects in this area, as exemplified in the present study, where we investigated the relative contribution of nitric oxide and independent mechanisms (hyperpolarizing factor) therein, as influenced by passive tension and the precontraction agent and in morpho-physiological correlation with arterial diameter along the vascular tree. We used isometric myography of rings from rat mesenteric arcade and its branches, alone or combined with recording of membrane potential in vascular myocytes. When nitric oxide production is blocked, endothelium-dependent relaxation is biphasic and increased by the following: higher resting tension, lower level of precontration, distal location and smaller arterial diameter (but depending on the contracting agent). Our findings have implications regarding the physiological relevance of data referring to the multiple mechanisms of endothelium-dependent relaxation in resistance arteries.
- Subjects
NITRIC oxide; ENDOTHELIUM; LABORATORY rats; ARTERIES; VASODILATION; VASCULAR smooth muscle
- Publication
Romanian Journal of Functional & Clinical, Macro & Microscopical Anatomy & of Anthropology / Revista Româna de Anatomie Functionala si Clinica, Macro si Microscopica si de Antropologie, 2011, Vol 10, Issue 3, p330
- ISSN
1583-4026
- Publication type
Article