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- Title
Concomitant Non-Small Cell Lung Cancer and Hairy Cell Leukemia in a Patient Harboring BRAF-V600E Mutation in Both Tissues: A Case Report.
- Authors
Mitsogianni, Maria; Mitsimponas, Nikolaos; Crespo, Felipe; Hartmann, Karl Axel; Klosterhalfen, Bernd; Haase, Sabine; Giagounidis, Aristoteles
- Abstract
The BRAF-V600E mutation has been established as a signature alteration occurring almost universally in hairy cell leukemia. Moreover, it can be detected in a small percentage of patients with non-small cell lung cancer. We report the case of a patient with a metastatic BRAF-V600E-mutated lung adenocarcinoma suffering from concomitant hairy cell leukemia. The identification of an identical BRAF mutation in both malignancies raises physiopathological considerations and might offer unique therapeutic strategies for this group of patients.
- Subjects
NON-small-cell lung carcinoma; HAIRY cell leukemia
- Publication
Case Reports in Oncology, 2018, Vol 11, Issue 1, p109
- ISSN
1662-6575
- Publication type
Case Study
- DOI
10.1159/000486640