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- Title
Unsafe testosterone-based dosing regimen of androgen deprivation therapy in patients with locally advanced or metastatic prostate cancer: a prematurely ended randomized controlled trial (MIDAS-trial).
- Authors
Mulder, Midas B.; Birnie, Erwin; van Dijck – van Boetzelaer, Caroline; van de Geijn, Gert-Jan; Boevé, Egbert; Westerman, Elsbeth M.; Hamberg, Paul
- Abstract
The article presents the results of a randomized controlled trial of extending the dosing interval of goserelin with a testosterone level-based dosing regimen in patients with locally advanced or metastatic prostate cancer. Topics discussed include the procedures used in the control and intervention group, adverse effect of the dosing algorithm on the testosterone level, and factors that contribute to the recovery time of the levels after androgen deprivation therapy (ADT) cessation.
- Subjects
THERAPEUTIC use of testosterone; TESTOSTERONE; GOSERELIN; COST control; TREATMENT effectiveness; RANDOMIZED controlled trials; DESCRIPTIVE statistics; STATISTICAL sampling; DATA analysis software; PROSTATE tumors
- Publication
Acta Oncologica, 2021, Vol 60, Issue 4, p539
- ISSN
0284-186X
- Publication type
Article
- DOI
10.1080/0284186X.2020.1862908