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- Title
The Effect of Early Enteral Nutrition Supplemented with Synbiotics On Lipid and Glucose Homeostasis in Critically Ill Patients: A Randomized Controlled Trial.
- Authors
Mohammadi, Mohammad Amin; Dabagh, Ali Ebrahimi; Sedaghat, Alireza; Rezvani, Reza; Khadem-Rezaiyan, Majid; Nematy, Mohsen; Seifi, Najmeh
- Abstract
Background: The aim of the present study was to investigate the effects of gut microbiota modulation through synbiotic supplementation on lipid and glucose homeostasis in tube-fed critically-ill adult patients. Methods: This study is placebo-controlled, parallel, single-center, double-blind clinical trial. 42 patients were randomly distributed in placebo and synbiotic groups to receive intervention for a maximum of 14 days. Serum levels of fasting glucose, total cholesterol, and triglycerides, insulin, and free fatty acid were obtained from blood sampling at baseline and the end of the study. Also, insulin resistance was determined by homeostasis model assessment of insulin resistance (HOMA-IR). Result: Fasting glucose level (Day0=87.84±15.51, Day14=83.76±8.71 mg/dl, P=0.51), fasting insulin level (Day0=9.46±7.31, Day14=7.97±5.19 mIU/L, P=1.00), and HOMA index (Day0=1.89±1.48, Day14=1.72±1.17, P=0.75) during the study were decreasing in both groups, but the decreases were not significant. Total cholesterol, triglyceride, and free fatty acid levels at the beginning of the study were 114.18±43.43 mg/dl, 146.59±53.99 mg/dl, 0.83±0.57 mmol/L, and at the end of the study were 129.10±39.05 mg/dl, 127.40±91.88 mg/dl, 0.88±0.77 mmol/L, respectively. None of these changes were significant either (P=0.99, P=0.38, P=0.90, respectively). Conclusions: According to our findings, synbiotics supplementation in critically ill patients has no significant effect on lipid and glucose profile.
- Subjects
SYNBIOTICS; ENTERAL feeding; CRITICALLY ill patient care; HOMEOSTASIS; BLOOD sampling; RANDOMIZED controlled trials
- Publication
Journal of Nutrition, Fasting & Health, 2022, Vol 10, p316
- ISSN
2821-2746
- Publication type
Article