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- Title
Vitamin D Levels Are Associated with Expression of SLE, but Not Flare Frequency.
- Authors
Squance, Marline L.; Reeves, Glenn E. M.; Tran, Huy A.
- Abstract
This study explores links between vitamin D deficiency (25(OH)D = 50 nmol/L) and serological autoimmunity (ANA > 1 : 80) and frequency of self-reported flares (SRF) in participants with clinical autoimmunity (SLE). 25(OH)D levels of 121 females were quantified and compared. The cohort consisted of 80ACR defined SLE patients and 41 age and sex matched controls. Association analysis of log2 (25(OH)D) levels and ANA 80 positivity was undertaken via two-sample .-tests and regression models. Significant differences were found for 25(OH)D levels (mean: control 74 nmol/L (29.5 ng/ml); SLE 58 nmol/L (23.1 ng/ml), P = 0.04), 25(OH)D deficiency (P = 0.02). Regression models indicate that, for a twofold rise in 25(OH)D level, the odds ratio (OR) for ANA-positivity drops to 36% of the baseline OR. No link was found between SRF-days and 25(OH)D levels. Our results support links between vitamin D deficiency and expression of serological autoimmunity and clinical autoimmunity (SLE). However, no demonstrable association between 25(OH)D and SRF was confirmed, suggesting independent influences of other flare-inducing factors. Results indicate that SLE patients have high risk of 25(OH)D deficiency and therefore supplementation with regular monitoring should be considered as part of patient management.
- Subjects
VITAMIN D deficiency; PROTEIN expression; SYSTEMIC lupus erythematosus; AUTOIMMUNITY; SEROLOGY; COHORT analysis; REGRESSION analysis; PATIENTS
- Publication
International Journal of Rheumatology, 2014, p1
- ISSN
1687-9260
- Publication type
Article
- DOI
10.1155/2014/362834