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- Title
Outcomes of regenerative treatment with rh PDGF- BB and rh FGF-2 for periodontal intra-bony defects: a systematic review and meta-analysis.
- Authors
Khoshkam, Vahid; Chan, Hsun‐Liang; Lin, Guo‐Hao; Mailoa, James; Giannobile, William V.; Wang, Hom‐Lay; Oh, Tae‐Ju
- Abstract
Background The aim was to evaluate the effects of recombinant human platelet-derived growth factor- BB (rh PDGF- BB) and recombinant human fibroblast growth factor-2 (rh FGF-2) on treating periodontal intra-bony defects, compared to the control (carrier alone). Methods Electronic and hand searches were performed to identify eligible studies. The weighed mean differences of linear defect fill ( LDF), probing depth ( PD) reduction, clinical attachment level ( CAL) gain and gingival recession ( GR) were calculated using random effect meta-analysis. Results The searches yielded 1018 articles, of which seven studies were included. Only one included study was considered at low risk of bias. The outcomes that reached statistical significance in comparison to carriers alone included: LDF (0.95 mm, 95% CI: 0.62-1.28 mm or 20.17%, 95% CI: 11.81-28.54%) and CAL gain (0.34 mm, 95% CI: 0.03-0.65 mm) for PDGF, and LDF (21.22%, 95% CI: 5.82-36.61%) for FGF-2. Conclusions Within the limits of this review, rh PDGF- BB demonstrated significantly more LDF and CAL gain; rh FGF-2 resulted in significantly higher percentage of LDF.
- Subjects
PERIODONTAL disease treatment; PLATELET-derived growth factor; BIOMEDICAL engineering; CONFIDENCE intervals; MEDICAL information storage &; retrieval systems; MEDLINE; META-analysis; ONLINE information services; REGENERATION (Biology); SYSTEMATIC reviews; TREATMENT effectiveness; THERAPEUTICS
- Publication
Journal of Clinical Periodontology, 2015, Vol 42, Issue 3, p272
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1111/jcpe.12354