We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The occurrence of cavum septi pellucidi enlargement is increased in bipolar disorder patients.
- Authors
Kim, Minue J; Lyoo, In Kyoon; Dager, Stephen R; Friedman, Seth D; Chey, Jeanyung; Hwang, Jaeuk; Lee, Yu‐Jin; Dunner, David L; Renshaw, Perry F
- Abstract
Objectives: This study was conducted to evaluate the prevalence of cavum septi pellucidi (CSP) enlargement in patients with bipolar disorder (BD) and healthy comparison subjects. Methods: The occurrence of enlarged CSP in patients with BD (n = 41, age 35.4 ± 10.8 years) and healthy volunteers (n = 41, age 35.3 ± 10.0 years) was studied using magnetic resonance imaging. The length of the CSP was measured by counting the number of consecutive resliced coronal 0.5-mm images in which the CSP was present. A CSP length ≥ 6 mm was a priori defined as abnormal enlargement of the CSP. Results: Bipolar subjects exhibited a significantly higher prevalence of abnormal CSP enlargement (8 of 41 subjects, 19.5%) than healthy comparison subjects (1 of 41 subjects, 2.4%) (logistic regression analysis: Wald statistic = 5.07, df = 1, p = 0.024). The prevalence of abnormally enlarged CSP was not significantly different between drug-naïve and drug-exposed bipolar subjects or when comparing bipolar I and II sub-diagnoses. Bipolar subjects with abnormal CSP enlargement had a significantly earlier onset of BD than those without (14.3 ± 3.6 versus 20.1 ± 7.4 years, respectively). Conclusions: The current study is the first to report an increased prevalence of abnormally enlarged CSP in a well-characterized bipolar population. Our finding that an abnormal enlargement of CSP, a neurodevelopmental abnormality, is associated with early onset of illness implicates early maturational processes as contributing to BD.
- Subjects
BIPOLAR disorder; MAGNETIC resonance imaging; CORPUS callosum; MENTAL illness; PATHOLOGICAL physiology; NEUROLOGY
- Publication
Bipolar Disorders, 2007, Vol 9, Issue 3, p274
- ISSN
1398-5647
- Publication type
Article
- DOI
10.1111/j.1399-5618.2007.00442.x