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- Title
Association of systemic chronic inflammation during pregnancy in different periods and its trajectories with preterm birth.
- Authors
Cheng, Haoyue; Zhu, Zhe; Chi, Peihan; Alifu, Xialidan; Zhuang, Yan; Si, Shuting; Qiu, Yiwen; Zhou, Haibo; Peng, Zhicheng; Yu, Yunxian
- Abstract
Problem: Systemic chronic inflammation (SCI) is a prevalent characteristic observed in various diseases originating from different tissues, while the association of SCI with preterm birth (PTB) remains uncertain. This study aimed to analyze the association between a nonspecific biomarker of SCI and PTB, while also exploring the trajectories of SCI in pregnant women at risk of PTB. Method of study: The study used data from the Electronic Medical Record System (EMRS) of a hospital in Zhejiang, China and 9226 pregnant women were included. The duration of pregnancy was categorized into four distinct periods: the first, early‐second, late‐second, and third trimester. Latent class trajectory modeling (LCTM) was used to identify the trajectories of SCI during pregnancy. Results: The elevated WBC counts in the late‐second (OR = 1.14, 95% CI: 1.06–1.23) and third (OR = 1.16, 95% CI: 1.09–1.24) trimester were both positively associated with an evaluated risk of PTB. Moreover, significant dose–response relationships were observed. There were three distinct SCI trajectories found: progressing SCI (2.89%), high SCI (7.13%), and low SCI (89.98%). Pregnant women with progressive SCI had the highest risk of PTB (OR = 3.03, 95% CI: 1.47–6.25). Conclusions: In conclusion, elevated SCI after 23 weeks was a risk factor for PTB in healthy women, even if the SCI indicator was within normal range. Pregnant women with progressive SCI during pregnancy had the highest risk of PTB.
- Subjects
ZHEJIANG Sheng (China); PREMATURE labor; HIGH-risk pregnancy; DURATION of pregnancy; PREGNANT women; PREGNANCY
- Publication
American Journal of Reproductive Immunology, 2024, Vol 91, Issue 5, p1
- ISSN
1046-7408
- Publication type
Article
- DOI
10.1111/aji.13848