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- Title
Nodal Gamma/Delta T Cell Lymphoma in Complete Remission following Allogeneic Bone Marrow Transplantation from an HLA-Matched Unrelated Donor.
- Authors
Aoyama, Yasutaka; Yamane, Takahisa; Hino, Masayuki; Ota, Kensuke; Hasegawa, Taro; Sakamoto, Chikahiko; Nakamae, Hirohisa; Yamamura, Ryousuke; Koh, Ki-Ryang; Takubo, Takayuki; Inoue, Takeshi; Tsubaki, Kazuo; Tatsumi, Noriyuki
- Abstract
Gamma/delta T cell lymphoma is very rare, and usually occurs as an extranodal tumor. We describe the case of a 16-year-old Japanese man with an unusual nodal gamma/delta T cell lymphoma with generalized lymphadenopathy and bone marrow involvement. No tumor involvement was observed in the liver, spleen, or nasal cavity. Examination for surface antigens on lymphoma cells revealed a unique phenotype, positive for CD3 and T cell receptor (TCR) gamma/delta, but negative for CD2. Genotypic analysis revealed the tumor to be of monoclonal origin and characterized by TCR gamma-chain gene rearrangement, but there was no rearrangement of the TCR beta-chain gene. Our patient’s tumor responded to combination chemotherapy and subsequent allogeneic bone marrow transplantation from an HLA-matched unrelated donor. He has remained well and free of disease for 35 months.Copyright © 2001 S. Karger AG, Basel
- Subjects
T cells; LYMPHOMAS; BONE marrow transplantation; BONE marrow cancer; TUMORS
- Publication
Acta Haematologica, 2001, Vol 105, Issue 1, p49
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000046533