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- Title
Double-blind test on the efficacy of methylcobalamin on sleep–wake rhythm disorders.
- Authors
Takahashi, K.; Okawa, M.; Matsumoto, M.; Mishima, K.; Yamadera, H.; Sasaki, M.; Ishizuka, Y.; Yamada, K.; Higuchi, T.; Okamoto, N.; Furuta, H.; Nakagawa, H.; Ohta, T.; Kuroda, K.; Sugita, Y.; Inoue, Y.; Uchimura, N.; Nagayama, H.; Miike, T.; Kamei, K.
- Abstract
The therapeutic effect of methylcobalamin (Met-12) on sleep–wake rhythm disorders was examined in a double-blind test. In the test group which was given a large dosage, a higher percentage of improvement was found compared to the control group with a small dosage, although the difference was not significant. The test group inconsistently showed significant improvement in both the sleep–wake cycle parameters and in clinical symptoms. The tendency was for the results to show a beneficial effect of Met-12 on rhythm disorders. However, because the percentage of improvement was low and significant improvement was inconsistent, Met-12 might be considered to have a low therapeutic potency and possible use as a booster for other treatment methods of the disorders.
- Subjects
SLEEP-wake cycle; THERAPEUTIC use of vitamin B12
- Publication
Psychiatry & Clinical Neurosciences, 1999, Vol 53, Issue 2, p211
- ISSN
1323-1316
- Publication type
Article
- DOI
10.1046/j.1440-1819.1999.00534.x