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- Title
Short-Term Hyperglycemic Dysregulation in Patients With Type 1 Diabetes Does Not Change Myocardial Triglyceride Content or Myocardial Function.
- Authors
Hammer, Sebastiaan; Jonker, Jacqueline T.; Lamb, Hildo J.; Van Der Meer, Rutger W.; Zondag, Wendy; Sepers, Jan M.; De Roos, Albert; Smit, Johannes W. A.; Romijn, Johannes A.
- Abstract
OBJECTIVE -- To evaluate the effects of hyperglycemia due to partial insulin deprivation on myocardial triglyceride (TG) content and myocardial function in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS -- Myocardial and hepatic TG content and left ventricular (LV) function were measured by magnetic resonance (MR) spectroscopy and MR imaging during optimal glucoregulation and after 24 h of partial insulin deprivation (n = 10). RESULTS -- Mean insulin infusion rate was 45 ± 5 units at baseline, whereas it was 27 ± 5 units during hyperglycemia (per 24 h, P < 0.001). Plasma glucose levels increased from 8.4 ± 0.6 to 15.9 ± 0.8 mmol/l (P < 0.001), and plasma levels of nonesterified fatty acids from 0.31 ± 0.05 to 0.46 ± 0.07 mmol/l (P = 0.015). Hyperglycemia had no effects on myocardial or hepatic TG content and LV function. CONCLUSIONS -- Short-term hyperglycemic dysregulation does not modulate myocardial or hepatic TG content or myocardial function, despite considerable metabolic adaptations.
- Subjects
HYPERGLYCEMIA; MYOCARDIUM; LIVER; DIABETES; INSULIN; TRIGLYCERIDES
- Publication
Diabetes Care, 2008, Vol 31, Issue 8, p1613
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/dc08-0513