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- Title
Inferring Cell Differentiation Processes Based on Phylogenetic Analysis of Genome-Wide Epigenetic Information: Hematopoiesis as a Model Case.
- Authors
Kanako O. Koyanagi
- Abstract
How cells divide and differentiate is a fundamental question in organismal development; however, the discovery of differentiation processes invarious cell types is laborious andsometimes impossible. Phylogenetic analysis is typically used to reconstruct evolutionary processes based on inherent characters. It could also be used to reconstruct developmental processes based on the developmental changes that occur during cell proliferation and differentiation. In this study, DNA methylation information from differentiated hematopoietic cells was used to perform phylogenetic analyses. The results were assessed for their validity in inferring hierarchical differentiation processes of hematopoietic cells and DNA methylation processes of differentiating progenitor cells. Overall, phylogenetic analyses based on DNA methylation information facilitated inferences regarding hematopoiesis.
- Subjects
CELL differentiation; HEMATOPOIESIS; MORPHOGENESIS; GENOMES; PHYLOGENY
- Publication
Genome Biology & Evolution, 2015, Vol 7, Issue 3, p699
- ISSN
1759-6653
- Publication type
Article
- DOI
10.1093/gbe/evv024