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- Title
Current enzyme-mediated insecticide resistance status of Aedes aegypti populations from a dengue-endemic city in southern Mexico.
- Authors
Solís-Santoyo, Francisco; Rodríguez, Américo D.; Black, William; Saavedra-Rodríguez, Karla; Sánchez-Guillén, Daniel; Castillo-Vera, Alfredo; González-Gómez, Rebeca; Delia López-Solis, Alma; Patricia Penilla-Navarro, Rosa
- Abstract
Objective. To identify the enzyme-mediated insecticide resistance in Aedes aegypti in Tapachula, Mexico. Materials and methods. Biochemical assays were undertaken to determine the enzyme levels in mosquitoes from 22 sites collected in 2018 and 2020 in Tapachula. Results of 2018 were correlated with the resistance to insecticides published. Results. Mosquitoes had higher levels than those of the susceptible strain in 2018 and 2020 respectively of a-esterases in 15 and 12 sites; ß-esterases in 7 and 6 sites; glutathione-S-transferases in 11 and 19 sites; ρNPA-esterases in 21 and 17 sites; and cytochromes P450 in 20 and 22 sites. In mosquitoes of 2018, there was a moderate correlation between previously documented Malathion resistance ratios and the insensitive acetylcholinesterase (r=0.459, p= 0.03). Conclusions. The elevated enzyme levels found indicate its contribution to the resistance to pyrethroids and organophosphates already published in mosquitoes from Tapachula. Bioassays using enzyme inhibitors resulted in greater mortality, confirming that metabolism contributes to resistance.
- Subjects
MEXICO; AEDES aegypti; INSECTICIDE resistance; MOSQUITOES; PYRETHROIDS; CHOLINESTERASE reactivators; MALATHION; CYPERMETHRIN
- Publication
Salud Pública de México, 2023, Vol 65, Issue 1, p19
- ISSN
0036-3634
- Publication type
Article
- DOI
10.21149/13910