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- Title
Antimicrobial action, cytotoxicity, calcium ion release, and pH variation of a calcium hydroxide‐based paste associated with Myracrodruon urundeuva Allemão extract.
- Authors
Krüger, Helington Castro; Francio, Jordano; Silva, Arthur Sorgatto da; Oliveira, Gabriela Silva Neubern de; Brancher, João Armando; Dantas, Letícia Ramos; Oliveira, Rodrigo Cardoso de; Tuon, Felipe Francisco; Carneiro, Everdan
- Abstract
The extract of Myracrodruon urundeuva Allemão (aroeira), as a vehicle, associated with calcium hydroxide (CH) paste was evaluated based on cell viability, antimicrobial action, calcium ion release, and pH variation. Calcium hydroxide with propylene glycol was used as control. The pH variation was measured at 3, 24, 72, 168, 140, 360, and 720 h and calcium ion release was measured on days 7, 15, and 30. Cell viability was assessed with NIH/3T3 cells using MTT and crystal violet assays, after 24, 48, and 72 h. Antibacterial activity was determined by the disc diffusion method, while microbial reduction (Enterococcus faecalis) was evaluated using the time–kill test. The CH paste formulated with aroeira showed antibacterial activity against Enterococcus faecalis and further did not interfere with pH, calcium ion release, or cell viability; moreover, the formulation had antimicrobial activity and could serve as a vehicle for CH paste.
- Subjects
NATIONAL Institutes of Health (U.S.); CALCIUM ions; CALCIUM hydroxide; CALCIUM; ENTEROCOCCUS faecalis; CELL survival; PROPYLENE glycols
- Publication
Australian Endodontic Journal, 2022, Vol 48, Issue 1, p170
- ISSN
1329-1947
- Publication type
Article
- DOI
10.1111/aej.12557