We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthetic Studies of 2,2‐Difluorobicyclo[1.1.1]pentanes (BCP‐F<sub>2</sub>): The Scope and Limitation of Useful Building Blocks for Medicinal Chemists.
- Authors
Ma, Xiaoshen; Pinto, Wilfredo; Pham, Luu N.; Sloman, David L.; Han, Yongxin
- Abstract
Bicyclo[1.1.1]pentanes (BCP's) have been applied in medicinal chemistry as bioisosteres for phenyl groups. In pursuit of novel BCP analogs, we reported the first synthesis of 2,2‐difluorobicyclo[1.1.1]pentanes (BCP–F2) in 2019. Herein, we detail the extension of our effort in the synthesis of BCP‐F2 analogs.
- Subjects
PENTANE; CHEMISTS; PHENYL group; PHARMACEUTICAL chemistry
- Publication
European Journal of Organic Chemistry, 2020, Vol 2020, Issue 29, p4581
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202000679