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- Title
Synthesis of Benzofuroquinolines via Phosphine‐Free Direct Arylation of 4‐Phenoxyquinolines in Air.
- Authors
Shanahan, Rachel M.; Hickey, Aobha; Reen, F. Jerry; O'Gara, Fergal; McGlacken, Gerard P.
- Abstract
A palladium‐catalysed, phosphine‐free, direct arylation of 4‐phenoxyquinolines, in air is described. Using an intramolecular approach, the ring‐closed products are formed in yields of up to 95 %. This approach allows access to a range of benzofuroquinolines. An array of functional groups on both the quinoline and phenoxy rings are tolerated. A palladium‐catalysed, phosphine‐free, direct arylation of 4‐phenoxyquinolines in air is described. Using intramolecular direct arylation, the ring‐closed products are formed in isolated yields of up to 95 %. This approach allows access to a range of benzofuroquinolines, and an array of functional groups on both the quinoline and phenoxy rings is tolerated.
- Subjects
PALLADIUM catalysts; QUINOLINE; PHOSPHINE; ARYLATION; CHEMICAL yield; FUNCTIONAL groups
- Publication
European Journal of Organic Chemistry, 2018, Vol 2018, Issue 44, p6140
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201800923