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- Title
Muscle and Liver Insulin Resistance Indexes Derived From the Oral Glucose Tolerance Test.
- Authors
Abdul-Ghani, Muhammad A.; Matsuda, Masafumi; Balas, Bogdan; DeFronzo, Ralph A.
- Abstract
OBJECTIVE -- To derive indexes for muscle and hepatic insulin sensitivity from the measurement of plasma glucose and insulin concentrations during an oral glucose tolerance test (OGTT). RESEARCH DESIGN AND METHODS -- A total of 155 subjects of Mexican-American origin (58 male and 97 female, aged 18-70 years, BMI 20-65 kg/m²) with normal glucose tolerance (n = 100) or impaired glucose tolerance (n = 55) were studied. Each subject received a 75-g OGTT and a euglycemic insulin clamp in combination with tritiated glucose. The OGTT-derived indexes of muscle and hepatic insulin sensitivity were compared with hepatic and muscle insulin sensitivity, which was directly measured with the insulin clamp, by correlation analysis. RESULTS -- The product of total area under curve (AUC) for glucose and insulin during the first 30 min of the OGTT (glucose0-30 [AUC] x insulin0-30[AUC]) strongly correlated with the hepatic insulin resistance index (fasting plasma insulin x basal endogenous glucose production) (r = 0.64, P < 0.0001). The rate of decay of plasma glucose concentration from its peak value to its nadir during the OGTT divided by the mean plasma insulin concentration (dG/dt / 1) strongly correlated with muscle insulin sensitivity measured with the insulin clamp (P = 0.78, P < 0.0001). CONCLUSIONS -- Novel estimates for hepatic and muscle insulin resistance from OGTT data are presented for quantitation of insulin sensitivity in nondiabetic subjects.
- Subjects
MUSCLES; LIVER; INSULIN resistance; BLOOD sugar; GLUCOSE tolerance tests; MEXICAN Americans
- Publication
Diabetes Care, 2007, Vol 30, Issue 1, p89
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/dc06-1519