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- Title
Modified BODE Index to Predict Mortality in Individuals With COPD: The Role of 4-Min Step Test.
- Authors
Vieira, Elaine B.; Degani-Costa, Luiza H.; Amorim, Beatriz C.; Oliveira, Lígia B.; Miranda-Silva, Talita; Sperandio, Priscila C. A.; Medeiros, Wladimir M.; Arbex, Flávio F.; Ramos, Roberta P.; Nery, Luiz E.
- Abstract
BACKGROUND: The BODE (body mass index, air-flow obstruction, dyspnea, exercise capacity) index is a composite prognostic marker that predicts mortality in COPD. It includes body mass index, air-flow obstruction, dyspnea score, and exercise capacity by using the 6-min walk distance. However, a 30-m-long corridor is necessary to perform the test and this limits its use in clinical practice. Step tests may elicit distinct physiologic responses compared with the 6-min walk test but are easy to perform in the office setting. We sought to investigate whether a 4-min step test would be a suitable surrogate of the 6-min walk test, in a modified BODE step index (simplified BODE index), to predict mortality in COPD. METHODS: Individuals with COPD performed a self-paced 4-min step test, and the simplified BODE index was calculated by replacing the 6-min walk distance by the number of steps climbed. Cutoff values were determined by receiver operating characteristic curve analysis as follows: score 0 for >60 steps; score 1 for 50-60 steps; score 2 for 40-49 steps; and score 3 for <40 steps. RESULTS: A total of 186 individuals with COPD were enrolled from 2011 to 2016 (60% males; mean ± SD age, 65 ± 9 y; mean ± SD FEV1, 50 ± 17 L). There were 36 deaths among the study cohort. The simplified BODE index was a prognostic marker, independent of cardiovascular comorbidities and oxygen desaturation (HR 1.12, confidence interval (CI) [1.03-1.22]). Individuals with simplified BODE index scores ≥ 7 were at higher risk of death from any cause (P < .001, log-rank test). CONCLUSIONS: This was the first study, to our knowledge, to show that the 4-min step test as a surrogate of exercise capacity in the BODE index (simplified BODE index) is an independent predictor of mortality in COPD and may help to spread its use among practicing physicians.
- Subjects
MORTALITY risk factors; CHI-squared test; CONFIDENCE intervals; CAUSES of death; DYSPNEA; EXERCISE tests; GAIT in humans; LONGITUDINAL method; OBSTRUCTIVE lung diseases; MEDICAL practice; MULTIVARIATE analysis; PHYSICIANS; RESPIRATION; RISK assessment; SPIROMETRY; STATISTICS; SURVIVAL analysis (Biometry); AEROBIC capacity; BODY movement; BODY mass index; PROPORTIONAL hazards models; RECEIVER operating characteristic curves; DATA analysis software; DESCRIPTIVE statistics; LOG-rank test
- Publication
Respiratory Care, 2020, Vol 65, Issue 7, p977
- ISSN
0020-1324
- Publication type
Article
- DOI
10.4187/respcare.06991