We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Relationship Between Skeletal Muscle Oxygenation and Systemic Oxygen Uptake During Exercise in Subjects With COPD: A Preliminary Study.
- Authors
Kazuyuki Tabira; Jun Horie; Hiromasa Fujii; Toshio Aida; Ken-Ichi Ito; Takahiko Fukumoto; Hidetaka Imagita; Hideki Ishihara
- Abstract
BACKGROUND: Muscle oxygenation correlates with systemic oxygen uptake (v̇O2 ) in normal subjects; however, whether this relationship exists in COPD patients remains unclear. The purpose of this study was to investigate the influence of skeletal muscle oxygenation on v̇O2during exercise in patients with COPD. METHODS: Eight subjects performed an incremental cycle ergometer exercise test. We measured ventilation and pulmonary gas exchange with a metabolic measurement system. We also continuously monitored SpO2, and measured tissue oxygen saturation (StO2 ) in the vastus lateralis with continuous-wave near-infrared spectroscopy. We calculated the muscle oxygen extraction rate (MOER) based on SpO2 and StO2. In addition, we calculated Pearson correlation coefficients to examine the relationships between the v̇O2obtained during exercise testing and the mean values of SpO2 , StO2, heart rate (HR), and MOER for each 30-second interval of the tests. Finally, we analyzed the relationships between the peak v̇O2and the slopes of HR/ v̇O2 , SpO2 / v̇O2, StO2 /̇O2, and MOER/ v̇O2 . RESULTS: With the increasing exercise intensity, many subjects showed a gradual decrease in StO2 and SpO2, but a gradual increase in HR and MOER. ̇O2was negatively correlated with StO2 and SpO2 , and was positively correlated with HR and MOER. However, peak ̇O2was not correlated with any of the slopes. CONCLUSIONS: ̇O2is highly influenced by oxygen utilization in exercising muscles, as well as by blood oxygenation levels and cardiac function. However, the impact of skeletal muscle utilization during exercise on peak ̇O2 varied greatly among the subjects.
- Subjects
ACTIVE oxygen in the body; STATISTICAL correlation; EXERCISE; EXERCISE tests; HEART beat; OBSTRUCTIVE lung diseases; PULMONARY gas exchange; RESEARCH funding; RESPIRATORY measurements; OXYGEN consumption; ERGOMETRY; VITAL capacity (Respiration); DATA analysis software; SKELETAL muscle; DESCRIPTIVE statistics
- Publication
Respiratory Care, 2012, Vol 57, Issue 10, p1602
- ISSN
0020-1324
- Publication type
Article
- DOI
10.4187/respcare.01602