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- Title
Evaluation of physico-mechanical properties and in vitro biocompatibility of compression molded HDPE based biocomposites with HA/Al<sub>2</sub>O<sub>3</sub> ceramic fillers and titanate coupling agents.
- Authors
Tripathi, Garima; Dubey, Ashutosh Kumar; Basu, Bikramjit
- Abstract
The present article demonstrates how the stiffness, hardness as well as the cellular response of bioinert high-density polyethylene (HDPE) can be significantly improved with combined addition of both bioinert and bioactive ceramic fillers. For this purpose, different amounts of hydroxyapatite and alumina, limited to a total of 40 wt %, have been incorporated in HDPE matrix. An important step in composite fabrication was to select appropriate solvent and optimal addition of coupling agent (CA). In case of chemically coupled composites, 2% Titanium IV, 2-propanolato, tris iso-octadecanoato-O was used as a CA. All the hybrid composites, except monolithic HDPE, were fabricated under optimized compression molding condition (140°C, 0.75 h, 10 MPa pressure). The compression molded composites were characterized, using X-ray diffraction, Fourier transformed infrared spectroscopy, and scanning electron microscopy. Importantly, in vitro cell culture and cell viability study (MTT) using L929 fibroblast and SaOS2 osteoblast-like cells confirmed good cytocompatibility properties of the developed hybrid composites. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
- Subjects
HIGH density polyethylene; CERAMICS; MATRICES (Mathematics); X-ray diffraction; THERMOPLASTICS; DUCTILITY
- Publication
Journal of Applied Polymer Science, 2012, Vol 124, Issue 4, p3051
- ISSN
0021-8995
- Publication type
Article
- DOI
10.1002/app.35339