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- Title
Mucormycosis in Organ and Stem Cell Transplant Recipients.
- Authors
Lanternier, Fanny; Sun, Hsin-Yun; Ribaud, Patricia; Singh, Nina; Kontoyiannis, Dimitrios P.; Lortholary, Olivier
- Abstract
Mucormycosis is a devastating invasive fungal disease whose incidence has increased during the past decade. Mucormycosis now represents a major threat in transplant recipients, accounting for 2% and 8% of invasive fungal infections in recent cohorts of solid-organ and allogeneic stem-cell transplant recipients, respectively. Mucormycosis most often occurs late, >3 months after transplantation, although cases occurring early have been observed, especially among liver transplant recipients and in cases of graft-transmitted infection. Recent guidelines have emphasized the direct examination of the involved fluid or tissue and culture from a sterile site as the most appropriate diagnostic strategy and the use of lipid formulations of amphotericin B and major surgery when feasible as the most appropriate first-line therapeutic strategy for mucormycosis in organ and stem cell transplant recipients.
- Subjects
MUCORMYCOSIS; STEM cell transplantation; COHORT analysis; COMPLICATIONS from organ transplantation; LIVER transplantation; TISSUE culture; AMPHOTERICIN B
- Publication
Clinical Infectious Diseases, 2012, Vol 54, Issue 11, p1
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/cis195