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- Title
The usability of neopterin in determining disease course in COVID-19.
- Authors
Ozatag, Duru Mıstanoglu; Korkmaz, Pınar; Keskin, Havva; Koçak, Havva
- Abstract
Objectives: To investigate the usability of neopterin in demonstrating the progression of COVID-19. As a result of uncontrolled activation of COVID-19 monocytes and macrophages, IFN gamma increases and the resulting inflammatory response causes organ damage. IFN released from T cells causes an increase in gamma neopterin levels. Therefore, measurement of neopterin levels can be used to indicate immune system activation and disease progression Methods: The study was carried out prospectively in two different centers. The patients were divided into, two groups (mild-moderate and severe) and clinical laboratory, imaging findings and neopterin levels at hospitalization were compared. Results: 100 patients were included in our study, 41 of these patients were male. Forty-six patients were identified as severe COVID-19. C-reactive protein, lymphocyte count, fibrinogen, D dimers, lactate dehydrogenase, procalcitonin, troponin and neopterin levels were significant in indicating disease severity. (p<0.05). In ROC analysis, 0.642 for neopterin, 0.698 C-reactive protein, 0.331 lymphocyte count, 0.679 procalcitonin, 0.633 fibrinogen, 0.667 D dimers, 0.655 troponin and 0.706 lactate dehydrogenase were detected and these values were significant. Conclusion: In our study, neopterin was detected as an important indicator in determining the course of COVID-19.
- Subjects
NEOPTERIN; COVID-19; DISEASE progression; LYMPHOCYTE count; LACTATE dehydrogenase; MEDULLARY thyroid carcinoma
- Publication
Saudi Medical Journal, 2023, Vol 44, Issue 8, p767
- ISSN
0379-5284
- Publication type
Article
- DOI
10.15537/smj.2023.44.8.20230365