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- Title
Formation of Strong Airway Irritants in Mixtures of Isoprene/Ozone and Isoprene/Ozone/Nitrogen Dioxide.
- Authors
Wilkins, Cornelius K.; Clausen, Per A.; Wolkoff, Peder; Larsen, S. Thor; Hammer, Maria; Larsen, Kjeld; Hansen, Vivi; Nielsen, Gunnar D.
- Abstract
We evaluated the airway irritation of isoprene, isoprene/ozone, and isoprene/ozone/nitrogen dioxide mixtures using a mouse bioassay, from which we calculated sensory irritation, bronchial constriction, and pulmonary irritation. We observed significant sensory irritation (approximately 50% reduction of mean respiratory rate) by dynamically exposing the mice, over 30 min, to mixtures of isoprene and O[sub3] or isoprene, 0[sub3], and NO[sub2]. The starting concentrations were approximately 4 ppm O[sub3] and 500 ppm isoprene (+ approximately 4 ppm NO[sub2]). The reaction mixtures after approximately 30 sec contained < 0.2 ppm O[sub3]. Addition of the effects of the residual reactants and the identified stable irritant products (formaldehyde, formic acid, acetic acid, methacrolein, and methylvinyl ketone) could explain only partially the observed sensory irritation. This suggests that one or more strong airway irritants were formed. It is thus possible that oxidation reactions of common unsaturated compounds may be relevant for indoor air quality. Key word: airway irritation, indoor air chemistry, isoprene, mouse irritation bioassay, nitrogen dioxide, ozone. Environ Health Perspect 109:937-941 (2001). [Online 24 August 2001] http://ehpnet1.niehs.nih.gov/dacs/2001/W9p937-94lwilkins/abstr act.html
- Subjects
ISOPRENE; NITROGEN dioxide; OXIDATION; AIRWAY (Anatomy)
- Publication
Environmental Health Perspectives, 2001, Vol 109, Issue 9, p937
- ISSN
0091-6765
- Publication type
Article
- DOI
10.1289/ehp.01109937