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- Title
Fruktozdan zengin beslenen sıçanlarda istemli fiziksel aktivitenin metabolik ve kardiyak işlevlere etkisi.
- Authors
Tayfur, Pınar; Palabıyık, Orkide; Uzun, Nurşen; Süt, Necdet; Vardar, Selma Arzu
- Abstract
Objective: Fructose-rich diet increases risk of cardiac diseaseand metabolic changes in the body. The aim of this study was to investigate the effect of voluntary physical activity on metabolic and cardiac functionsin fructose-rich feed rats. Material and Methods: Male Wistar albino rats, were divided into groups as control (C;n=7), fructose group which was fed 10% fructose to drinking water (F;n=7) and fructose-activity group (FA;n=7) housed with a running wheel during 10 weeks. Daily fluid intake and body weight of rats were measured weekly. Serum glucose, triglycerides, total cholesterol, HDL, LDL levels were assessed using an enzymatic method. Insulin, TNF-α, and IL-6 levels were determined by ELISA method. Left ventricular developed pressure, maximum and minimum rate of change were recorded by Langendorff apparatus. The weights of the heart, lungs and liver were determined. Results: Weight gain between the one and the ten weeks were significantly lower for FA group (95,1±14,3 g), in comparison to F (109,0±6,6 g) and C (113,4±10,9 g) groups (p=0,04 and p=0,03). Liver weight was significantly higher for F group (11,8±1,0 g), in comparison to C (9,7±1,3 g) and FA (10,2±0,7 g) groups (p=0,01 and p=0,01). Serum measurements were not different between groups. The maximum rate of change was found higher in FA group (2351,6±442,2) than F (1320,7±542,2) and C groups (1756,5±468,7) (p=0,01 and p=0,05). Conclusion: The findings of the study suggest that voluntary physical activity may play a role in reducing weight gain and enhancing cardiac contractility in rats fed with 10% fructose in drinking water for ten weeks.
- Publication
Journal of General Medicine / Genel Tıp Dergisi, 2019, Vol 29, Issue 2, p65
- ISSN
1301-191X
- Publication type
Article
- DOI
10.15321/geneltipder.2019253583